Hemophilia description :
An inherited blood disorder, hemophilia occurs when the blood does not clot
normally. This eMedTV article provides an overview of hemophilia, including
information about how it is diagnosed and treated, and offers links to additional
information.
f)Mild hemophilia may not cause any symptoms for
years, so treatment may not be needed.
Moderate hemophilia may require treatment only when bleeding occurs.
People with moderate hemophilia should learn to recognize the signs and
symptoms of bleeding so that they can get medical attention as quickly as
possible. They may also receive hemophilia treatment to prevent bleeding that
could occur when participating in some activities.
Severe hemophilia usually requires long-term or shorter-term preventive
therapy to prevent bleeding that could cause permanent damage to joints,
muscles, or other parts of the body. However, some people with severe
hemophilia receive treatment only when bleeding occurs.
e) hemophilia is a X-linked recessive pattern, where
the mutated gene is located on the X chromosome. This results in a higher
frequency of occurrence in males, who only have on X chromosome; since females havetwo X chromosomes, they need two mutated genes
to have the disorder, or else they become carriers. Carriers rarely have
symptoms, 10 percent have mild problems with bleeding.
g) Blood donors are now screened, and commercial products are now heat-treated
to kill the viruses. Genetic screening can identify carriers of
hemophilia, and the status of fetuses can be now be ascertained early in
pregnancy.
h) Thanks to the development of clotting factor products, most people with
hemophilia can look forward to a near-normal life span.
There are three main complications that may develop in people with hemophilia:
* Joint destruction – Multiple episodes of bleeding into joints can
result in severe joint damage.
* Blood-borne infection – Blood testing and purification techniques
have improved markedly over the years. It is now exceedingly rare for or
HIV infections to be transmitted through blood products.
* Development of inhibitor antibodies – People who are treated with
clotting factors can develop inhibitor antibodies. These are proteins that
decrease the effectiveness of the clotting treatment. When this occurs,
treatment can become complicated and expensive